RapamycinFungusV1, Main, Exploration, bibRecord, 000456

The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.

Identifieur interne : 000456 ( Main/Exploration ); précédent : 000455; suivant : 000457

The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.

Auteurs : Marie-Anne Deprez [Belgique] ; Elja Eskes [Belgique] ; Joris Winderickx [Belgique] ; Tobias Wilms [Belgique]

Source :

FEMS yeast research [ 1567-1364 ] ; 2018.

RBID : pubmed:29788208

Descripteurs français

English descriptors

KwdEn :
- Cytoplasm (metabolism), Gene Expression Regulation, Fungal (MeSH), Metabolic Networks and Pathways (MeSH), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (physiology), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (MeSH), Transcription Factors (genetics), Transcription Factors (metabolism).
MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- genetics : Saccharomyces cerevisiae.
- metabolism : Cytoplasm, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- physiology : Saccharomyces cerevisiae.
- Gene Expression Regulation, Fungal, Metabolic Networks and Pathways, Signal Transduction.

Abstract

The concept of ageing is one that has intrigued mankind since the beginning of time and is now more important than ever as the incidence of age-related disorders is increasing in our ageing population. Over the past decades, extensive research has been performed using various model organisms. As such, it has become apparent that many fundamental aspects of biological ageing are highly conserved across large evolutionary distances. In this review, we illustrate that the unicellular eukaryotic organism Saccharomyces cerevisiae has proven to be a valuable tool to gain fundamental insights into the molecular mechanisms of cellular ageing in multicellular eukaryotes. In addition, we outline the current knowledge on how downregulation of nutrient signaling through the target of rapamycin (TOR)-Sch9 pathway or reducing calorie intake attenuates many detrimental effects associated with ageing and leads to the extension of yeast chronological lifespan. Given that both TOR Complex 1 (TORC1) and Sch9 have mammalian orthologues that have been implicated in various age-related disorders, unraveling the connections of TORC1 and Sch9 with yeast ageing may provide additional clues on how their mammalian orthologues contribute to the mechanisms underpinning human ageing and health.

DOI: 10.1093/femsyr/foy048
PubMed: 29788208

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000548
to stream Main, to step Curation: 000548

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.</title>
<author><name sortKey="Deprez, Marie Anne" sort="Deprez, Marie Anne" uniqKey="Deprez M" first="Marie-Anne" last="Deprez">Marie-Anne Deprez</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eskes, Elja" sort="Eskes, Elja" uniqKey="Eskes E" first="Elja" last="Eskes">Elja Eskes</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Winderickx, Joris" sort="Winderickx, Joris" uniqKey="Winderickx J" first="Joris" last="Winderickx">Joris Winderickx</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilms, Tobias" sort="Wilms, Tobias" uniqKey="Wilms T" first="Tobias" last="Wilms">Tobias Wilms</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29788208</idno>
<idno type="pmid">29788208</idno>
<idno type="doi">10.1093/femsyr/foy048</idno>
<idno type="wicri:Area/Main/Corpus">000548</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000548</idno>
<idno type="wicri:Area/Main/Curation">000548</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000548</idno>
<idno type="wicri:Area/Main/Exploration">000548</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.</title>
<author><name sortKey="Deprez, Marie Anne" sort="Deprez, Marie Anne" uniqKey="Deprez M" first="Marie-Anne" last="Deprez">Marie-Anne Deprez</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eskes, Elja" sort="Eskes, Elja" uniqKey="Eskes E" first="Elja" last="Eskes">Elja Eskes</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Winderickx, Joris" sort="Winderickx, Joris" uniqKey="Winderickx J" first="Joris" last="Winderickx">Joris Winderickx</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilms, Tobias" sort="Wilms, Tobias" uniqKey="Wilms T" first="Tobias" last="Wilms">Tobias Wilms</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee</wicri:regionArea>
<placeName><region type="province" nuts="2">Province du Brabant flamand</region>
<settlement type="town">Heverlee</settlement>
<settlement type="city">Louvain</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">FEMS yeast research</title>
<idno type="eISSN">1567-1364</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytoplasm (metabolism)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Metabolic Networks and Pathways (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (physiology)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cytoplasme (métabolisme)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (physiologie)</term>
<term>Transduction du signal (MeSH)</term>
<term>Voies et réseaux métaboliques (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cytoplasm</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytoplasme</term>
<term>Facteurs de transcription</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation, Fungal</term>
<term>Metabolic Networks and Pathways</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Régulation de l'expression des gènes fongiques</term>
<term>Transduction du signal</term>
<term>Voies et réseaux métaboliques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The concept of ageing is one that has intrigued mankind since the beginning of time and is now more important than ever as the incidence of age-related disorders is increasing in our ageing population. Over the past decades, extensive research has been performed using various model organisms. As such, it has become apparent that many fundamental aspects of biological ageing are highly conserved across large evolutionary distances. In this review, we illustrate that the unicellular eukaryotic organism Saccharomyces cerevisiae has proven to be a valuable tool to gain fundamental insights into the molecular mechanisms of cellular ageing in multicellular eukaryotes. In addition, we outline the current knowledge on how downregulation of nutrient signaling through the target of rapamycin (TOR)-Sch9 pathway or reducing calorie intake attenuates many detrimental effects associated with ageing and leads to the extension of yeast chronological lifespan. Given that both TOR Complex 1 (TORC1) and Sch9 have mammalian orthologues that have been implicated in various age-related disorders, unraveling the connections of TORC1 and Sch9 with yeast ageing may provide additional clues on how their mammalian orthologues contribute to the mechanisms underpinning human ageing and health.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29788208</PMID>
<DateCompleted><Year>2019</Year>
<Month>04</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>04</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1567-1364</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>18</Volume>
<Issue>5</Issue>
<PubDate><Year>2018</Year>
<Month>08</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>FEMS yeast research</Title>
<ISOAbbreviation>FEMS Yeast Res</ISOAbbreviation>
</Journal>
<ArticleTitle>The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/femsyr/foy048</ELocationID>
<Abstract><AbstractText>The concept of ageing is one that has intrigued mankind since the beginning of time and is now more important than ever as the incidence of age-related disorders is increasing in our ageing population. Over the past decades, extensive research has been performed using various model organisms. As such, it has become apparent that many fundamental aspects of biological ageing are highly conserved across large evolutionary distances. In this review, we illustrate that the unicellular eukaryotic organism Saccharomyces cerevisiae has proven to be a valuable tool to gain fundamental insights into the molecular mechanisms of cellular ageing in multicellular eukaryotes. In addition, we outline the current knowledge on how downregulation of nutrient signaling through the target of rapamycin (TOR)-Sch9 pathway or reducing calorie intake attenuates many detrimental effects associated with ageing and leads to the extension of yeast chronological lifespan. Given that both TOR Complex 1 (TORC1) and Sch9 have mammalian orthologues that have been implicated in various age-related disorders, unraveling the connections of TORC1 and Sch9 with yeast ageing may provide additional clues on how their mammalian orthologues contribute to the mechanisms underpinning human ageing and health.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deprez</LastName>
<ForeName>Marie-Anne</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eskes</LastName>
<ForeName>Elja</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winderickx</LastName>
<ForeName>Joris</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wilms</LastName>
<ForeName>Tobias</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Functional Biology, KU Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>FEMS Yeast Res</MedlineTA>
<NlmUniqueID>101085384</NlmUniqueID>
<ISSNLinking>1567-1356</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="C530964">SCH9 protein, S cerevisiae</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D003593" MajorTopicYN="N">Cytoplasm</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053858" MajorTopicYN="N">Metabolic Networks and Pathways</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>11</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>04</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>4</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29788208</ArticleId>
<ArticleId IdType="pii">4980911</ArticleId>
<ArticleId IdType="doi">10.1093/femsyr/foy048</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Belgique</li>
</country>
<region><li>Province du Brabant flamand</li>
</region>
<settlement><li>Heverlee</li>
<li>Louvain</li>
</settlement>
</list>
<tree><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Deprez, Marie Anne" sort="Deprez, Marie Anne" uniqKey="Deprez M" first="Marie-Anne" last="Deprez">Marie-Anne Deprez</name>
</region>
<name sortKey="Eskes, Elja" sort="Eskes, Elja" uniqKey="Eskes E" first="Elja" last="Eskes">Elja Eskes</name>
<name sortKey="Wilms, Tobias" sort="Wilms, Tobias" uniqKey="Wilms T" first="Tobias" last="Wilms">Tobias Wilms</name>
<name sortKey="Winderickx, Joris" sort="Winderickx, Joris" uniqKey="Winderickx J" first="Joris" last="Winderickx">Joris Winderickx</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000456 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000456 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29788208
   |texte=   The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29788208" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.

The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki